Questions about the effectiveness of your dog’s tick and flea treatment
CAN CREDELIO® (LOTILANER) have an impact on flea allergy dermatitis (FAD) in a dog?
Credelio can be used as part of a treatment strategy for the control of FAD. In the U.S. field study, dogs in the Credelio treatment group with signs of FAD showed an improvement in clinical signs associated with FAD as a direct result of eliminating fleas.
DOES BATHING AFFECT CREDELIO'S EFFICACY?
Credelio is an oral medication that circulates in a dog’s bloodstream. Specific bathing studies have not been conducted, but because Credelio is a systemic medication and not applied topically, bathing would not be expected to have any effect on the efficacy. Credelio, unlike topical products, offers dog owners a convenient way to administer flea and tick control that won’t interfere with medically required or other frequent bathing.
DOES SEEING FLEAS ON A DOG TREATED WITH CREDELIO MEAN THAT CREDELIO IS NOT WORKING?
Credelio kills adult fleas quickly and effectively when used monthly according to the label directions. Remember that all animals in the household should be treated with an approved flea product to minimize the likelihood of flea reinfestation.
Regardless of the product used to kill the fleas, a dog can continue to be exposed to the fleas that live in the environment. If these fleas jump onto a dog and feed, they will be killed by Credelio.
Any fleas seen on a dog within a month after the dog has received Credelio are likely from the environment. These "new" fleas will be killed quickly and effectively.
WHY WOULD A DOG STILL HAVE TICKS AFTER A DOSE OF CREDELIO?
Credelio is a systemic medication, meaning that ticks have to bite a dog to be exposed to Credelio and for Credelio to start to work. It could be that the ticks you are seeing are those that have just recently crawled onto the dog and have not yet started to feed (and, therefore, have not yet been exposed to Credelio).
Dead ticks may remain attached to a dog. Before starting its blood meal, a tick may securely attach to a pet’s skin by secreting an adhesive compound into the bite wound or by anchoring its longer hypostome (mouthparts).2 On a treated dog, dead ticks might passively remain anchored and can easily be removed.
WHAT SHOULD I DO IF I MISS GIVING A DOSE OF CREDELIO?
If a dose is missed, administer Credelio with food and resume a monthly dosing schedule to minimize the opportunity for tick and flea re-infestations. Consult your veterinarian about any concerns you may have about ticks and fleas due to the late/missed dose.
DOES CREDELIO HAVE TO BE GIVEN WITH FOOD?
Credelio must be administered with food or given within 30 minutes of feeding. Feeding ensures your dog achieves peak blood levels and exposure, which is necessary for initial and ongoing efficacy.
How long does it take Credelio to get rid of fleas?
Credelio has a rapid onset of action and starts to kill fleas in just 4 hours. In a well-controlled U.S. laboratory study, Credelio demonstrated 100% effectiveness against adult fleas within 12 hours after administration, up to day 35.
IS CREDELIO EFFECTIVE IN KILLING FLEA EGGS, LARVAE OR PUPAE, EITHER ON A DOG OR IN THE ENVIRONMENT?
Credelio acts to kill adult fleas and, in a speed-of-kill study, Credelio killed 100% of fleas on dogs within 12 hours of administration, up to day 35.1 Adult female fleas begin to lay eggs within 20-24 hours of taking her first blood meal.5 Since Credelio works fast*, killing 100% of fleas within 12 hours for the entire month, Credelio kills fleas before they can lay eggs.
*Credelio starts killing fleas in 4 hours and kills 99% within 8 hours for 35 days. Credelio is greater than 97% effective against labeled tick species 48 hours after administration or infestation for 30 days. In a controlled European study, Credelio starts killing ticks (Ixodes ricinus) in 4 hours.
HOW DOES CREDELIO WORK SO FAST?
Credelio works fast because it is absorbed rapidly and achieves peak plasma levels quickly. When given with food, Credelio reaches peak blood levels within 2 hours of administration.4*Credelio starts killing fleas in 4 hours and kills 99% within 8 hours for 35 days. Credelio is greater than 97% effective against labeled tick species 48 hours after administration or infestation for 30 days. In a controlled European study, Credelio starts killing ticks (Ixodes ricinus) in 4 hours.
HOW FAST DOES CREDELIO BEGIN TO KILL TICKS? ONCE ADMINISTERED, DOES CREDELIO CONTINUE TO KILL TICKS THROUGH THE END OF THE MONTH?
In a well-controlled laboratory study, Credelio started to kill ticks (Ixodes ricinus) within 4 hours of administration, with 98.7% of ticks killed within 8 hours1. Credelio has a sustained speed-of-kill throughout the month and is effective against newly acquired Ixodes ricinus ticks within 8 hours, with an efficacy of 94.3% when measured at 7, 14, 21 and 28 days post-treatment3. At 12 hours after infestation, lotilaner sustained effectiveness of at least 94.2% up to day 35 after treatment.3
DOES A TICK/FLEA HAVE TO BITE A DOG TO BE KILLED BY CREDELIO?
Yes. Credelio is a systemic medication, which means that ticks/fleas have to feed in order to be exposed to lotilaner, the active ingredient.